I've had Ubuntu Karmic installed in both my Desktop and EEEPC since just after the release day, once installed I was quite impressed. Everything worked well, I was in awe over the X-splash effect and the cinematic shut down plus the improvement in boot up and shut down speed. I even like the extras such as Empathy, Evolution and the new Software Centre. A few weeks in though and some updates later every thing's going tits up. My FaceBook plugin for Empathy gave in the ghost, Gwibber has been very twitchy and Kaffeine pre 1.0 is pants.
I may look into trying to fix these annoyances or maybe stick it out in hope an update will fix them for me, I don't know if I want to spend my time tweeking till it works. A part of me wishes that I'd stayed with Jaunty but hope Karmic will improve seeing as we're heading into an LTS edition in April. Small annoyances they may-be but if they don't get fixed it'll just bug the hell out of me and I may make the switch to another Distro like Mint or something, Hell I might even give Slackware a go!